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Technologie der Mikrosystemtechnik
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Grundlagen der Elektrotechnik
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Mikrosystemtechnik
Bioelektronik
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Veroeffentlichungen

  • Ciba, Manuel, Bestel, Robert, Nick, Christoph, Ferraz de Arruda, Guilherme, Peron, Thomas, Henrique, Comin César, da Fontoura Costa, Luciano, Aparecido Rodrigues, Francisco, Thielemann, Christiane, 2020. Comparison of Different Spike Train Synchrony Measures Regarding Their Robustness to Erroneous Data from Bicuculline-Induced Epileptiform Activity. In: Neural Computation. 32(3), S. 1 – 25.
  • Flachs, Dennis, Emmerich, Florian, Roth, Gian-Luca, Hellmann, Ralf, Thielemann, Christiane, 2019. Laser-bonding of FEP/FEP interfaces for a flexiblemanufacturing process of ferroelectrets. In: Journal of Physics: Conference Series. 1407(012107), S. 1 – 5.
  • De Blasi, Stefano, Ciba, Manuel, Bahmer, Andreas, Thielemann, Christiane, 2019. Total spiking probability edges: A cross-correlation based method for effective connectivity estimation of cortical spiking neurons. In: Journal of Neuroscience Methods. 312(312), S. 169 – 181.
  • Körbitzer, Berit, Krauß, Peter, Belle, Stefan, Schneider, Jörg, Thielemann, Christiane, 2019. Electrochemical Characterization of Graphene Microelectrodes for Biological Applications. In: ChemNanoMat. 2019(5:4), S. 427 – 435.
  • Ciba, Manuel, Mayer, Margot, Thielemann, Christiane, 2019. Experimental setup to investigate the effect of psychedelics on in vitro neuronal networks.
  • Köhler, Tim, Wölfel, Maximilian, Ciba, Manuel, Bochtler, Ulrich, Thielemann, Christiane, 2018. Terrestrial Trunked Radio (TETRA) exposure of neuronal in vitro networks. In: Environmental Research. 2018(162), S. 1 – 7. Volltext verfügbar unter
  • Mayer, Margot, Arrizabalaga, Onetsine, Lieb, Florian, Ciba, Manuel, Ritter, Sylvia, Thielemann, Christiane, 2018. Electrophysiological investigation of human embryonic stem cell derived neurospheres using a novel spike detection algorithm. In: Biosensors and Bioelectronics. 2018(100), S. 462 – 468. Volltext verfügbar unter
  • Heselich, Anja, Frieß, Johannes, Ritter, Sylvia, Benz, Naja, Layer, Paul, Thielemann, Christiane, 2018. High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro. In: Life Sciences in Space Research. 2018(16), S. 93 – 100.
  • Flachs, Dennis, Köhler, Tim, Thielemann, Christiane, 2018. Transparent poly(3,4-ethylenedioxythiophene)-based microelectrodes for extracellular recording. In: Biointerphases. 2018(13:041008), S. 1 – 1.
  • Mayer, Margot, Arrizabalaga, Onetsine, Schröder, Insa, Ritter, Sylvia, Thielemann, Christiane, 2018. Human Embryonic Stem Cell Derived Neurospheres – 2D and 3D Cell Culture in one sample.
  • Ciba, Manuel, Thielemann, Christiane, 2018. Synchrony changes on different time-scales during in vitro neuronal network development.
  • Allig, Sebastian, Mayer, Margot, Thielemann, Christiane, 2018. Workflow for bioprinting of cell-laden bioink. In: Lekar a technika – Clinician and Technology. 48(2), S. 46 – 51. Volltext verfügbar unter
  • Lieb, Florian, Stark, Hans-Georg, Thielemann, Christiane, 2017. A stationary wavelet transform and a time-frequency based spike detection algorithm for extracellular recorded data. In: Journal of Neural Engineering. 2017(14), S. 1 – 13.
  • Emmerich, Florian, Thielemann, Christiane, 2017. Optimizing dimensions of unipolar Teflon-FEP piezoelectrets with micro-system-technology. In: Journal of Physics: Conference Series. 2018(1052), S. 1 – 4. Volltext verfügbar unter
  • Ciba, Manuel, Isomura, Takuya, Jimbo, Yasuhiko, Bahmer, Andreas, Thielemann, Christiane, 2017. Spike-contrast: A novel time scale independent and multivariate measure of spike train synchrony. In: Journal of Neuroscience Methods. 2018(293), S. 136 – 143.
  • Bestel, Robert, Appali, Revathi, van Rienen, Ursula, Thielemann, Christiane, 2017. Effect of Morphologic Features of Neurons on the Extracellular Electric Potential: A Simulation Study Using Cable Theory and Electro-Quasi-Static Equations. In: Neural Computation. 2017(29), S. 2955 – 2978.
  • Kupnik, Mario, Thielemann, Christiane, 2017. In vitro platform for acoustic and electrophysiological investigations of ultrasound stimulation. In: Brain Stimulation. 10(2), S. 501.
  • Ciba, Manuel, Bahmer, Andreas, Thielemann, Christiane, 2017. Application of spike train synchrony measure Spike‑contrast to quantify the effect of bicuculline on cortical networks grown on microelectrode arrays. In: BMC Neuroscience.
  • Oster, Stefan, Daus, Andreas, Erbes, Christian, Goldhammer, Michael, Bochtler, Ulrich, Thielemann, Christiane, 2016. Long‐term electromagnetic exposure of developing neuronal networks: A flexible experimental setup. In: Bioelectromagnetics. 2016(37), S. 264 – 278.
  • Köhler, Tim, Wölfel, Maximilian, Bochtler, Ulrich, Thielemann, Christiane, 2016. TETRA specific long-term exposure of neuronal in vitro networks. In: BioEM2016.
  • Emmerich, Florian, Thielemann, Christiane, 2016. Real-space measurement of potential distribution in PECVD ONO electrets by Kelvin probe force microscopy. In: Nanotechnology. 2016(27), S. 1 – 10. Volltext verfügbar unter
  • Samhaber, Robert, Schottdorf, Manuel, El Hady, Ahmed, Bröking, Kai, Daus, Andreas, Thielemann, Christiane, Stühmer, Walter, Wolf, Fred, 2016. Growing neuronal islands on multi-electrode arrays using an accurate positioning-μCP device. In: Journal of Neuroscience Methods. 2016(257), S. 194 – 203.
  • Mayer, Margot, Arrizabalaga, Onetsine, Ritter, Sylvia, Thielemann, Christiane, 2016. Human Embryonic Stem Cell Derived Neurospheres - A Novel Three Dimensional Model For Neurotoxicological Studies. In: Frontiers.
  • Körbitzer, Berit, Krauß, Peter, Schneider, Jörg, Thielemann, Christiane, 2016. Characterization Of Graphene-Coated Microelectrode Arrays For Recording And Stimulation Of Neuronal Cells. In: Frontiers.
  • Nick, Christoph, Hock, Christina, Emmerich, Florian, Belle, Stefan, Thielemann, Christiane, Asmus, Tim, Loose, Thomas, Wienand, Karlheinz, 2015. Ultrathin gold as sensor platform for biomolecules. In: 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), Changchun, China.
  • Emmerich, Florian, Thielemann, Christiane, 2015. Patterning of PMMA by gold-nanoparticle initiated localized decomposition. In: 2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), Changchun, China.
  • Nick, Christoph, Schlaak, Helmut, Thielemann, Christiane, 2015. Simulation and Measurement of Neuroelectrodes' Characteristics with Integrated High Aspect Ratio Nano Structures. In: AIMS Journal. 2015(2), S. 189 – 202.
  • Nick, Christoph, Yadav, Sandeep, Joshi, Ravi, Schneider, Jörg, Thielemann, Christiane, 2015. A three-dimensional microelectrode array composed of vertically aligned ultra-dense carbon nanotube networks. In: Applied Physics Letters. 2015(107), S. 1 – 1.
  • Frieß, Johannes, Heselich, Anja, Ritter, Sylvia, Haber, Angelina, Kaiser, Nicole, Layer, Paul, Thielemann, Christiane, 2015. Electrophysiologic and cellular characteristics of cardiomyocytes after X-ray irradiation. In: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2015(777), S. 1 – 10.
  • Mayer, Margot, Arrizabalaga, Onetsine, Ritter, Sylvia, Thielemann, Christiane, 2015. Human embryonic stem cell derived neurospheres form functional networks on microelectrode arrays.
  • Körbitzer, Berit, Krauß, Peter, Nick, Christoph, Schneider, Jörg, Thielemann, Christiane, 2015. Graphene electrodes for recording and stimulation of neural cells. In: ICREA Workshop on Graphene Nanobiosensors. Barcelona, Spanien:
  • Frieß, Johannes, Heselich, Anja, Ritter, Sylvia, Layer, Paul, Thielemann, Christiane, 2014. Combined effects of ionizing radiation and cardio-active drugs on human iPSC-derived cardiomyocytes.
  • Daus, Andreas, Bestel, Robert, Thielemann, Christiane, 2014. A multivariate spike-detection algorithm to assess activity patterns of three-dimensional in vitro models. In: MEA Meeting 2014, Reutlingen, Germany. S. 194 – 195. ISSN 2199-1596.
  • Nick, Christoph, Yadav, Sandeep, Joshi, Ravi, Schneider, Jörg, Thielemann, Christiane, 2014. Growth of Cortical Neurons Grown on Randomly Oriented and Vertically Aligned Dense Carbon Nanotube Networks. In: Beilstein Journal of Nanotechnology. S. 1575 – 1579.
  • Helm, Alexander, Frank, Simon, Frieß, Johannes, Thielemann, Christiane, Durante, Marco, Ritter, Sylvia, 2014. Electrophysiological response of mouse embryonic stem cell-derived cardiomyocytes after X-ray and C-ion exposure.
  • Mayer, Margot, Müller, Benedikt, Kadereit, Suzanne, Ritter, Sylvia, Thielemann, Christiane, 2014. Human neurospheres on microelectrode arrays: a model to investigate ionizing radiation effects on neuronal network communication.
  • Nick, Christoph, Lippert, Paul, Quednau, Sebastian, Schlaak, Helmut, Thielemann, Christiane, 2014. Gold Nanopillar Microelectrodes on Low Temperature Curing Polyimide for the Interface with Electrogenic Cells. In: Middle East Conference on Biomedical Engineering. Doha, Qatar: S. 55 – 58. ISBN 978-1-4799-4799-7.
  • Emmerich, Florian, Thielemann, Christiane, 2014. Direct Visualisation of Stored Charges in PECVD ONO-Layers by Kelvin-Probe-Force-Microscopy. In: 15th International Symposium on Electrets ISE. Baltimore, USA:
  • Stern, Maike, Nick, Christoph, Thielemann, Christiane, 2014. A Novel LabVIEW based Multi-Channel Closed-Loop Stimulator. In: 9th International Meeting on Substrate-Integrated Micro-electrode Arrays. Reutlingen, Germany:
  • Nick, Christoph, Schlaak, Helmut, Thielemann, Christiane, 2014. PEDOT:PSS coated Gold Nanopillar Micro-electrodes for Neural Interfaces. In: 4th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale. Taipeh, Taiwan:
  • Nick, Christoph, Thielemann, Christiane, 2014. Are Carbon Nanotube Microelectrodes Manufactured from Dispersion Stable Enough for Neural Interfaces?. In: BioNanoScience. 2014(4 / 3), S. 216 – 225.
  • Daus, Andreas, Oster, Stefan, Erbes, Christian, Goldhammer, Michael, Bochtler, Ulrich, Thielemann, Christiane, 2013. Electromagnetic exposure of neuronal networks on microelectrode arrays. In: U.R.S.I. Landesausschuss in der Bundesrepublik Deutschland e.V., Kleinheubacher Tagung, Miltenberg, Abstracts. S. 29 – 30.
  • Oster, Stefan, Daus, Andreas, Goldhammer, Michael, Bochtler, Ulrich, Thielemann, Christiane, 2013. A Flexible RF Exposure Setup for Long-term Electrophysiological Investigations on Biological Samples in Vitro. In: Progress In Electromagnetics Research Symposium Abstracts, Stockholm, Schweden.
  • Frieß, Johannes, Ritter, Sylvia, Daus, Andreas, Layer, Paul, Thielemann, Christiane, Heselich, Anja, 2013. Electrophysiologic and Molecular Characteristics of Cardiomyocytes after Heavy Ion Irradiation in the frame of the ESA IBER-10 Program. In: Heavy Ion in Therapie and Space Radiation Symposium (HITSRS2013), 2013, Chiba, Japan.
  • Frieß, Johannes, Heselich, Anja, Ritter, Sylvia, Layer, Paul, Thielemann, Christiane, 2013. Effect of X-rays and titanium ions on cardiomyocyte cultures.
  • Nick, Christoph, Daus, Andreas, Bestel, Robert, Goldhammer, Michael, Steger, Frederik, Thielemann, Christiane, 2013. DrCell - a software tool for the analysis of cell signals recorded with extracellular microelectrodes. In: Signal processing: an international journal (SPIJ). 7(2), S. 96 – 109.
  • Nick, Christoph, Quednau, Sebastian, Sarwar, Reza, Schlaak, Helmut, Thielemann, Christiane, 2013. High Aspect Ratio Gold Nanopillars on Microelectrodes for Neural Interfaces. In: Microsystem Technologies Media. 20/10-11, S. 1849 – 1857. ISSN 0946-7076.
  • Helm, Alexander, Frank, Simon, Frieß, Johannes, Thielemann, Christiane, Durante, Marco, Ritter, Sylvia, 2013. Purified cultures of mouse embryonic stem cell-derived cardiomyocytes of electrophysiological studies with ionizing radiation.
  • Nick, Christoph, Bestel, Robert, Steger, Frederik, Thielemann, Christiane, 2013. Spike Detection, Sorting and Propagation of Cell Signals Recorded with Extracellular Microelectrodes, Engineering in Medicine and Biology Society. In: IEMBS’13, 35th Annual International Conference of the IEEE.
  • Nick, Christoph, Quednau, Sebastian, Sarwar, Reza, Thielemann, Christiane, Schlaak, Helmut, 2013. Fabrication of high aspect ratio gold nanopillars on microelectrodes for the interface with electrogenic cells. In: HARMNST - 10th international workshop on high aspect ratio micro and nano system technologies, Berlin. S. 212 – 213.
  • Obmann, Julia, Polt, Christopher, Loose, Thomas, Asmus, Tim, Wienand, Karlheinz, Thielemann, Christiane, 2013. Novel Resistive Bioaffinity Sensor based on Ultra-Thin Gold Films. In: 3rd International Conference on Bio-Sensing Technology 2013, Sitges, Spain.
  • Nick, Christoph, Quednau, Sebastian, Sarwar, Reza, Thielemann, Christiane, Schlaak, Helmut, 2013. Gold-Nanodrähte auf Mikroelektroden zur extrazellulären Ableitung elektrogener Zellen. In: Mikrosystemtechnik Kongress. Aachen, Deutschland: VDE Verlag,
  • Frieß, Johannes, Heselich, Anja, Ritter, Sylvia, Thielemann, Christiane, 2013. Electrophysiological characteristics of cardiomyocytes after heavy ion exposure. In: Jahrestagung der Gesellschaft für biologische Strahlenforschung. Darmstadt, Deutschland:
  • Mayer, Margot, Ritter, Sylvia, Thielemann, Christiane, 2013. Electrophysiological Effects of Ionising Radiation on Cortical Rat Neurons in vitro.
  • Nick, Christoph, Joshi, Ravi, Schneider, Jörg, Thielemann, Christiane, 2012. Low Temperature Substrate Transfer Technique for 3D Vertically Aligned Carbon Nanotube Architectures. In: International Journal of Surface Science and Engineering. 6(3), S. 246 – 246.
  • Yilmazoglu, Oktay, Al-Daffaie, Shihab, Hartnagel, Hans, Joshi, Ravi, Yadav, Sandeep, Schneider, Jörg, Nick, Christoph, Thielemann, Christiane, 2012. CNT photocathodes based on GaAs high-frequency photoswitches. In: 25th International Vacuum Nanoelectronics Conference, 9 - 13 July 2012, Jeju, South Korea.
  • Steger, Frederik, Frieß, Johannes, Daus, Andreas, Ritter, Sylvia, Thielemann, Christiane, 2012. Analysis of electrophysiological characteristics of cardiomyocytes following radiation exposure. In: 8th International Meeting on Substrate-Integrated Microelectrode Arrays. S. 153. ISSN 2194-5519.
  • Nick, Christoph, Joshi, Ravi, Schneider, Jörg, Thielemann, Christiane, 2012. Three-Dimensional Carbon Nanotube Electrodes for Extracellular Recording of Cardiac Myocytes. In: Biointerphases, 2012. S. 58.
  • Materna, Miriam, Helm, Alexander, Hessel, Petra, Frieß, Johannes, Thielemann, Christiane, Pignalosa, Diana, Mäntele, Werner, Durante, Marco, Ritter, Sylvia, 2012. First electrophysiological studies on mouse embryonic stem cell-derived cardiomyocytes.
  • Thielemann, Christiane, Ritter, Sylvia, Layer, Paul, Frieß, Johannes, Daus, Andreas, Steger, Frederik, Heselich, Anja, 2012. IBER10 - Cellular effects of space radiation with relevance to cardiovascular diseases. In: European Space Agency - Life in Space for Life on Earth. Aberdeen, Schottland, UK:
  • Daus, Andreas, Layer, Paul, Thielemann, Christiane, 2012. A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations. In: Sensors and actuators B: Chemical. 165(1), S. 53 – 58.
  • Frieß, Johannes, Heselich, Anja, Ritter, Sylvia, Daus, Andreas, Layer, Paul, Thielemann, Christiane, 2012. Electrophysiological Effects of Heavy Ion Irradiation on Cardiomyocytes.
  • Nick, Christoph, Heinlein, Thorsten, Schneider, Jörg, Thielemann, Christiane, 2012. 3D Carbon Nanotube Electrodes for Sensing of Neural Activity. In: Elsevier World Congress on Biosensors. Cancun, Mexiko:
  • Bestel, Robert, Daus, Andreas, Thielemann, Christiane, 2012. A novel automated spike sorting algorithm with adaptable feature extraction. In: Journal of Neuroscience Methods. 211(1), S. 168 – 178.
  • Nick, Christoph, Thielemann, Christiane, Joshi, Ravi, Schneider, Jörg, 2011. Niedrigtemperatur-Transfer von vertikal ausgerichteten Kohlenstoff Nanoröhren auf Mikrostrukturen. In: Mikro-Nano-Integration - 3. GMM-Workshop, Stuttgart, Deutschland, 2011.
  • Nick, Christoph, Joshi, Ravi, Schlaak, Helmut, Schneider, Jörg, Thielemann, Christiane, 2011. Multi electrode array with carbon nanotube electrodes for the extra-cellular detection of action potentials. In: MikroSystemTechnik Kongress 2011, Darmstadt.
  • Daus, Andreas, Goldhammer, Michael, Layer, Paul, Thielemann, Christiane, 2011. Electromagnetic exposure of scaffold-free three-dimensional cell culture systems. In: Bioelectromagnetics. 32(5), S. 351 – 359. ISSN 1521-186X.
  • Emmerich, Florian, Thielemann, Christiane, 2011. Observation of Thermal Discharge in Nanopatterned Electrets by Kelvin-Probe-Microscopy. In: 14th International Symposium on Elecrets, 2011, Montpellier, France. S. 149 – 150. ISBN 978-1-4577-1023-0 und ISSN 2153-3253.
  • Daus, Andreas, Bestel, Robert, Thielemann, Christiane, 2011. Spike Detection, Refinement And Interpretation Of Recordings In Three-Dimensional In Vitro Systems. In: World Congress of Regenerative Medicine & Stem Cells 2011, Beijing, China.
  • Steger, Frederik, Ritter, Sylvia, Daus, Andreas, Frieß, Johannes, Thielemann, Christiane, 2011. Analysis of electrophysiological characteristics of cardiomyocytes following radiation exposure.
  • Thielemann, Christiane, Ritter, Sylvia, Layer, Paul, Frieß, Johannes, Daus, Andreas, Steger, Frederik, Heselich, Anja, 2011. Cellular effects of space radiation with relevance to cardiovascular diseases. In: Life in Space for Life on Earth. S. 560.
  • Daus, Andreas, Goldhammer, Michael, Bochtler, Ulrich, Thielemann, Christiane, 2010. A new approach for the investigation of long-term effects of RF radiation on cells. In: 28th Progress In Electromagnetics Research Symposium 2010, Cambridge.
  • Daus, Andreas, Goldhammer, Michael, Thielemann, Christiane, 2010. Using three-dimensional cell culture systems on Microelectrode arrays for biosensing applications. In: 7th international Meeting on subtrate-intergrated microelectrode arrays, Reutlingen. S. 314 – 315. ISBN 978-3-938345-08-5.
  • Daus, Andreas, Thielemann, Christiane, 2010. Spheroids on microelectrode arrays: A highly sensitive system for biosensing applications. In: European Journal of cell biology. 89 Sonderheft 1, S. 67 – 68.
  • Goldhammer, Michael, Daus, Andreas, Thielemann, Christiane, Bochtler, Ulrich, 2009. Flexible measurement setup for electromagnetic exposition of biological samples. In: BioEM 2009, Davos, Switzerland.
  • Daus, Andreas, Goldhammer, Michael, Bochtler, Ulrich, Thielemann, Christiane, 2009. Electromagnetic exposition of neuronal networks in vitro. In: Radiofrequency fields and health.
  • Arnheiter, Frank, Asmus, Tim, Loose, Thomas, Wienand, Karlheinz, Thielemann, Christiane, 2009. Metal-nanosensor for the detection of biomolecules. In: Mikro-Nano Integration (GMM-Fachbericht 60),. ISBN 978-3-8007-3155-8.
  • Jungblut, Melanie, Knoll, Wolfgang, Thielemann, Christiane, Pottek, Mark, 2009. Triangular neuronal networks on microelectrode arrays: an approach to improve the properties of low-density networks for extracellular recording. In: Biomed Microdevices, 2009. 11(6), S. 1269 – 1278.
  • Daus, Andreas, Hasenkopf, Matthias, Thielemann, Christiane, 2009. Novel 3D cell culture systems for electromagnetic exposure studies. In: BioEM 2009, Davos, Switzerland.
  • Pottek, Mark, Soerensen, Soren, Knoll, Wolfgang, Howitz, Steffen, Thielemann, Christiane, 2006. Cell-based Microfluidic System for Drug Screening Applications. In: MST news, 2006. 1, S. 38 – 39.
  • Li, Jing, Thielemann, Christiane, Reuning, Ute, Johannsmann, Diethelm, 2005. Monitoring of Integrin-Mediated Adhesion of Human Ovarian Cancer Cells to Model Protein surfaces by Quartz crystal Resonators: Evaluation in the Impedance Analysis Mode. In: Biosensors and Bioelectronics. S. 1333 – 1334.
  • Pax, Markus, Rieger, Janosch, Thielemann, Christiane, Johannsmann, Diethelm, 2005. Cell-Based Biosensors for Drug Screening: Detection of the Beating Rate of Cardiac Myocytes with a Quartz crystal Resonator. In: Analyst. S. 1451 – 1458.

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