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Prof. Dr. Georg Hildenbrand

About me
  1. Position Professor Faculty of Engineering and Computer Science
  2. Contact
    1. Würzburger Straße 45
      Room C1/04/102
      63743 Aschaffenburg
    2. georg.hildenbrand(at)th-ab.de
    3. + 49 60 21 4206 - 971

 

My professional areas of expertise are bioinformatics, biophysics and medical technology. The aim of my research is to gain new insights for the development of more precise diagnostic and treatment options. Astro biological studies on the emergence of life in extreme environments complement my research experience. 

 

Expertise

  • Bioinformatics

  • Biophysics

  • Medical technology

  • Research Focus:

    • High-resolution microscopy in research on the genome architecture, DNA repair and receptor clusters in membranes
    • Computer-based comparative genomics and determination of conserved structures
    • Astrobiology: Origin and development of life in extreme environments

Vita

Degree / work experience Institution / company Timescale
Professor faculty of engineering sciences TH Aschaffenburg 2022
Research and teacher in biophysics and astrobiology Kirchhoff-Institute for Physics, University of Heidelberg 2007 – 2022
Assistant physician radiotherapy University Hospital Mannheim 2012 – 2019
Assistant physician neurology SRH Kurpfalzkrankenhaus Heidelberg 2012
Medical studies, license to practice medicine University Mainz 2006 – 2011
Laboratory manager of the microscopy laboratory Faculty of medical physics and biophysics, University of Münster 2005
Study abroad Ecole Normale Supérieure, Paris 2004
Doctorate in Physics University of Heidelberg 1999 – 2003
Studied physics and biology, Diploma in biology University of Heidelberg 1991 – 1999

Publications

  • Döhring, Thorsten, Krivanekova, Lucia, Pregler, Jan, Hildenbrand, Georg, 2025. Radiation measurements in the stratosphere by the balloon experiment ASTRABAX. SPIE. S. 1353109-1 — 1353109-11. Abstract
  • Döhring, Thorsten, Pregler, Jan, Krivanekova, Lucia, Hildenbrand, Georg, 2025. Strahlungsmessungen beim Erstflug des Stratosphärenballon-Experiments ASTRABAX. DGaO. S. 1 — 1. Abstract Fulltext
  • Stanik, Eva, Döhring, Thorsten, Pregler, Jan, Stollenwerk, Manfred, Hildenbrand, Georg, 2024. Spectral measurements and life science experiments using extreme radiation exposures at high altitude. S. 130240M — 130240M. Abstract Fulltext
  • Döhring, Thorsten, Stanik, Eva, Pregler, Jan, Stollenwerk, Manfred, Hildenbrand, Georg, 2024. Forschung zu Strahlenschäden mit dem Stratosphärenballon-Experiment ASTRABAX. S. 1 — 1. Abstract Fulltext
  • Stanik, Eva, Döhring, Thorsten, Pregler, Jan, Stollenwerk, Manfred, Hildenbrand, Georg, 2024. Spectral measurements and life science experiments using extreme radiation exposures at high altitude. Abstract Fulltext
  • Schäfer, Myriam, Hildenbrand, Georg, Hausmann, Michael, 2024. Impact of Gold Nanoparticles and Ionizing Radiation on Whole Chromatin Organization as Detected by Single-Molecule Localization Microscopy. In: International Journal of Molecular Sciences. 25(23). ISSN 1422-0067. Abstract
  • Döhring, Thorsten, Stanik, Eva, Pregler, Jan, Stollenwerk, Manfred, Hildenbrand, Georg, 2024. Forschung zu Strahlenschäden mit dem Stratosphärenballon-Experiment ASTRABAX. S. 1 — 2. Abstract Fulltext
  • Solov’yov, Andrey V., Verkhovtsev, Alexey V., Mason, Nigel J., Amos, Richard A., Bald, Ilko, Baldacchino, Gérard, Dromey, Brendan, Falk, Martin, Fedor, Juraj, Gerhards, Luca, Hausmann, Michael, Hildenbrand, Georg, Hrabovský, Miloš, Kadlec, Stanislav, Kočišek, Jaroslav, Lépine, Franck, Ming, Siyi, Nisbet, Andrew, Ricketts, Kate, Sala, Leo, Schlathölter, Thomas, Wheatley, Andrew E. H., Solov’yov, Ilia A., 2024. Condensed Matter Systems Exposed to Radiation: Multiscale Theory, Simulations, and Experiment. In: Chemical Reviews. 124(13), S. 8014 — 8129. ISSN 0009-2665. Abstract
  • Henn, Lukas, Sievers, Aaron, Hausmann, Michael, Hildenbrand, Georg, 2023. Specific Patterns in Correlations of Super-Short Tandem Repeats (SSTRs) with G+C Content, Genic and Intergenic Regions, and Retrotransposons on All Human Chromosomes. In: Genes. 15(1). ISSN 2073-4425. Abstract
  • Sievers, Aaron, Sauer, Liane, Bisch, Marc, Sprengel, Jan, Hausmann, Michael, Hildenbrand, Georg, 2023. Moderation of Structural DNA Properties by Coupled Dinucleotide Contents in Eukaryotes. In: Genes. 14(3). ISSN 2073-4425. Abstract
  • Erenpreisa, Jekaterina, Giuliani, Alessandro, Yoshikawa, Kenichi, Falk, Martin, Hildenbrand, Georg, Salmina, Kristine, Freivalds, Talivaldis, Vainshelbaum, Ninel, Weidner, Jonas, Sievers, Aaron, Pilarczyk, Götz, Hausmann, Michael, 2023. Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change. In: International Journal of Molecular Sciences. 24(3). ISSN 1422-0067. Abstract
  • Hausmann, Michael, Hildenbrand, Georg, Pilarczyk, Götz, 2022. Networks and Islands of Genome Nano-architecture and Their Potential Relevance for Radiation Biology. In: Results and Problems in Cell Differentiation Cham: Springer International Publishing. S. 3 — 34. ISBN 9783031065729. Abstract
  • Rodener, Daniel, Schäfer, Myriam, Hausmann, Michael, Hildenbrand, Georg, 2022. Assessing the Potential for Liquid Solvents from X-ray Sources: Considerations on Bodies Orbiting Active Galactic Nuclei. In: Galaxies. 10(5). ISSN 2075-4434. Abstract
  • Hildenbrand, Georg, Paschek, Klaus, Schäfer, Myriam, Hausmann, Michael, 2022. Cryovolcanism in the Solar System and beyond: Considerations on Energy Sources, Geological Aspects, and Astrobiological Perspectives. In: Astronomy and Planetary Science - From Cryovolcanism to Black Holes and Galactic Evolution IntechOpen. ISBN 9781803561196. Abstract
  • Dobešová, Lucie, Gier, Theresa, Kopecna, Olga, Pagáčová, Eva, Vičar, Tomáš, Bestvater, Felix, Toufar, Jiří, Bačíková, Alena, Kopel, Pavel, Fedr, Radek, Hildenbrand, Georg, Falková, Iva, Falk, Martin, Hausmann, Michael, 2022. Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells. In: Pharmaceutics. 14(1). ISSN 1999-4923. Abstract
  • Sievers, Aaron, Sauer, Liane, Hausmann, Michael, Hildenbrand, Georg, 2021. Eukaryotic Genomes Show Strong Evolutionary Conservation of k-mer Composition and Correlation Contributions between Introns and Intergenic Regions. In: Genes. 12(10). ISSN 2073-4425. Abstract
  • Paschek, Klaus, Roßmann, Arthur, Hausmann, Michael, Hildenbrand, Georg, 2021. Analysis of Tidal Accelerations in the Solar System and in Extrasolar Planetary Systems. In: Applied Sciences. 11(18). ISSN 2076-3417. Abstract
  • Paschek, Klaus, Roßmann, Arthur, Hausmann, Michael, Hildenbrand, Georg, 2021. Analysis of Tidal Accelerations in the Solar System and in Extrasolar Planetary Systems. Abstract
  • Hausmann, Michael, Neitzel, Charlotte, Hahn, Hannes, Winter, Ruth, Falkova, Iva, Heermann, Dieter W., Pilarczyk, Götz, Hildenbrand, Georg, Scherthan, Harry, Falk, Martin, 2021. Space and Time in the Universe of the Cell Nucleus after Ionizing Radiation Attacks: A Comparison of Cancer and Non-Cancer Cell Response. Basel Switzerland: MDPI. Abstract
  • Bartosova, Maria, Ridinger, David, Marinovic, Iva, Heigwer, Jana, Zhang, Conghui, Levai, Eszter, Westhoff, Jens H., Schaefer, Franz, Terjung, Stefan, Hildenbrand, Georg, Krunic, Damir, Bestvater, Felix, Hausmann, Michael, Schmitt, Claus Peter, Zarogiannis, Sotirios G., 2021. An Experimental Workflow for Studying Barrier Integrity, Permeability, and Tight Junction Composition and Localization in a Single Endothelial Cell Monolayer: Proof of Concept. In: International Journal of Molecular Sciences. 22(15). ISSN 1422-0067. Abstract
  • Bartosova, Maria, Zhang, Conghui, Schaefer, Betti, Herzog, Rebecca, Ridinger, David, Damgov, Ivan, Levai, Eszter, Marinovic, Iva, Eckert, Christoph, Romero, Philipp, Sallay, Peter, Ujszaszi, Akos, Unterwurzacher, Markus, Wagner, Anja, Hildenbrand, Georg, Warady, Bradley A., Schaefer, Franz, Zarogiannis, Sotirios G., Kratochwill, Klaus, Schmitt, Claus Peter, 2021. Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis. In: Circulation Research. 129(5). ISSN 0009-7330. Abstract
  • Bartosova, Maria, Schaefer, Betti, Zhang, Conghui, Herzog, Rebecca, Ridinger, David, Damgov, Ivan, Levai, Eszter, Marinovic, Iva, Eckert, Christoph, Romero, Philipp, Sallay, Peter, Ujszaszi, Akos, Unterwurzacher, Markus, Wagner, Anja, Hildenbrand, Georg, Warady, Bradley, Schaefer, Franz, Zarogiannis, Sotirios G., Kratochwill, Klaus, Schmitt, Claus Peter, 2021. Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis. In: Nephrology Dialysis Transplantation. 36(Supplement_1). ISSN 0931-0509. Abstract
  • Hausmann, Michael, Falk, Martin, Neitzel, Charlotte, Hofmann, Andreas, Biswas, Abin, Gier, Theresa, Falkova, Iva, Heermann, Dieter W., Hildenbrand, Georg, 2021. Elucidation of the Clustered Nano-Architecture of Radiation-Induced DNA Damage Sites and Surrounding Chromatin in Cancer Cells: A Single Molecule Localization Microscopy Approach. In: International Journal of Molecular Sciences. 22(7). ISSN 1422-0067. Abstract
  • Hausmann, Michael, Neitzel, Charlotte, Bobkova, Elizaveta, Nagel, David, Hofmann, Andreas, Chramko, Tatyana, Smirnova, Elena, Kopecna, Olga, Pagáčová, Eva, Boreyko, Alla, Krasavin, Evgeny, Falkova, Iva, Heermann, Dieter W., Pilarczyk, Götz, Hildenbrand, Georg, Bestvater, Felix, Falk, Martin, 2020. Single Molecule Localization Microscopy Analyses of DNA-Repair Foci and Clusters Detected Along Particle Damage Tracks. In: Frontiers in Physics. ISSN 2296-424X. Abstract
  • Hausmann, Michael, Lee, Jin-Ho, Sievers, Aaron, Krufczik, Matthias, Hildenbrand, Georg, 2020. COMBinatorial Oligonucleotide FISH (COMBO-FISH) with Uniquely Binding Repetitive DNA Probes. In: The Nucleus New York, NY: Springer US. S. 65 — 77. ISBN 9781071607626. Abstract
  • Falk, Martin, Wolinsky, Michael, Veldwijk, Marlon R., Hildenbrand, Georg, Hausmann, Michael, 2020. Gold nanoparticle enhanced radiosensitivity of cells: considerations and contradictions from model systems and basic investigations of cell damaging for radiation therapy. In: Nanoparticle Enhanced Radiation Therapy IOP Publishing. S. 10 — 1. ISBN 9780750323963. Abstract
  • Hausmann, Michael, Pilarczyk, Götz, Maus, Emanuel, Hesser, Jürgen, Hildenbrand, Georg, 2020. Super-resolution microscopy of nanogold-labelling. In: Nanoparticle Enhanced Radiation Therapy IOP Publishing. S. 11 — 1. ISBN 9780750323963. Abstract
  • Hausmann, Michael, Lee, Jin-Ho, Hildenbrand, Georg, 2020. 3D DNA FISH for analyses of chromatin-nuclear architecture. In: Epigenetics Methods Elsevier. S. 399 — 418. ISBN 9780128194140. Abstract
  • Pagáčová, Eva, Štefančíková, Lenka, Schmidt-Kaler, Franz, Hildenbrand, Georg, Vičar, Tomáš, Depeš, Daniel, Lee, Jin-Ho, Bestvater, Felix, Lacombe, Sandrine, Porcel, Erika, Roux, Stéphane, Wenz, Frederik, Kopecna, Olga, Falková, Iva, Hausmann, Michael, Falk, Martin, 2019. Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy. In: International Journal of Molecular Sciences. 20(3). ISSN 1422-0067. Abstract
  • Lee, Jin-Ho, Bobkova, Elizaveta, Gier, Theresa, Gote, Martin, Schmidt-kaler, Fanz, Brieger, Emily, Maus, Emanuel, Krufczik, Matthias, Chojowski, Robert, Korn, Friederike, Sarah, Schumann, Scherthan, Harry, Falkova, Iva, Falk, Martin, Hausmann, Michael, Hildenbrand, Georg, 2019. Mechanisms and Challenges for Understanding Radiation Induced Changes in Chromatin Nanoarchitecture. In: DRO 2018 Abstract
  • Sievers, Aaron, Wenz, Frederik, Hausmann, Michael, Hildenbrand, Georg, 2018. Conservation of k-mer Composition and Correlation Contribution between Introns and Intergenic Regions of Animalia Genomes. In: Genes. 9(10). ISSN 2073-4425. Abstract
  • Eryilmaz, Marion, Schmitt, Eberhard, Krufczik, Matthias, Theda, Franziska, Lee, Jin-Ho, Cremer, Christoph, Bestvater, Felix, Schaufler, Wladimir, Hausmann, Michael, Hildenbrand, Georg, 2018. Localization Microscopy Analyses of MRE11 Clusters in 3D-Conserved Cell Nuclei of Different Cell Lines. In: Cancers. 10(1). ISSN 2072-6694. Abstract
  • Bobkova, Elizaveta, Depes, Daniel, Lee, Jin-Ho, Jezkova, Lucie, Falkova, Iva, Pagacova, Eva, Kopecna, Olga, Zadneprianetc, Mariia, Bacikova, Alena, Kulikova, Elena, Smirnova, Elena, Bulanova, Tatiana, Boreyko, Alla, Krasavin, Evgeny, Wenz, Frederik, Bestvater, Felix, Hildenbrand, Georg, Hausmann, Michael, Falk, Martin, 2018. Recruitment of 53BP1 Proteins for DNA Repair and Persistence of Repair Clusters Differ for Cell Types as Detected by Single Molecule Localization Microscopy. In: International Journal of Molecular Sciences. 19(12). ISSN 1422-0067. Abstract
  • Hildenbrand, Georg, Metzler, Philipp, Pilarczyk, Götz, Bobu, Vladimir, Kriz, Wilhelm, Hosser, Hiltraud, Fleckenstein, Jens, Krufczik, Matthias, Bestvater, Felix, Wenz, Frederik, Hausmann, Michael, 2018. Dose enhancement effects of gold nanoparticles specifically targeting RNA in breast cancer cells. In: PLOS ONE. 13(1). ISSN 1932-6203. Abstract
  • Hausmann, Michael, Ilić, Nataša, Pilarczyk, Götz, Lee, Jin-Ho, Logeswaran, Abiramy, Borroni, Aurora, Krufczik, Matthias, Theda, Franziska, Waltrich, Nadine, Bestvater, Felix, Hildenbrand, Georg, Cremer, Christoph, Blank, Michael, 2017. Challenges for Super-Resolution Localization Microscopy and Biomolecular Fluorescent Nano-Probing in Cancer Research. In: International Journal of Molecular Sciences. 18(10). ISSN 1422-0067. Abstract
  • Krufczik, Matthias, Sievers, Aaron, Hausmann, Annkathrin, Lee, Jin-Ho, Hildenbrand, Georg, Schaufler, Wladimir, Hausmann, Michael, 2017. Combining Low Temperature Fluorescence DNA-Hybridization, Immunostaining, and Super-Resolution Localization Microscopy for Nano-Structure Analysis of ALU Elements and Their Influence on Chromatin Structure. In: International Journal of Molecular Sciences. 18(5). ISSN 1422-0067. Abstract
  • Sievers, Aaron, Bosiek, Katharina, Bisch, Marc, Dreessen, Chris, Riedel, Jascha, Froß, Patrick, Hausmann, Michael, Hildenbrand, Georg, 2017. K-mer Content, Correlation, and Position Analysis of Genome DNA Sequences for the Identification of Function and Evolutionary Features. In: Genes. 8(4). ISSN 2073-4425. Abstract
  • Ngwa, Wilfred, Boateng, Francis, Kumar, Rajiv, Irvine, Darrell J., Formenti, Silvia, Ngoma, Twalib, Herskind, Carsten, Veldwijk, Marlon R., Hildenbrand, Georg, Hausmann, Michael, Wenz, Frederik, Hesser, Jürgen, 2017. Smart Radiation Therapy Biomaterials. In: International Journal of Radiation Oncology*Biology*Physics. 97(3), S. 624 — 637. ISSN 0360-3016. Abstract
  • Moser, Felipe, Hildenbrand, Georg, Müller, Patrick, Al Saroori, Alexander, Biswas, Abin, Bach, Margund, Wenz, Frederik, Cremer, Christoph, Burger, Nina, Veldwijk, Marlon R., Hausmann, Michael, 2016. Cellular Uptake of Gold Nanoparticles and Their Behavior as Labels for Localization Microscopy. In: Biophysical Journal. 110(4), S. 947 — 953. ISSN 0006-3495. Abstract
  • Bosiek, Katharina, Hausmann, Michael, Hildenbrand, Georg, 2016. Perspectives on Comets, Comet-like Asteroids, and Their Predisposition to Provide an Environment That Is Friendly to Life. In: Astrobiology. 16(4), S. 311 — 323. ISSN 1531-1074. Abstract
  • Stuhlmüller, Michael, Schwarz-Finsterle, Jutta, Fey, Evelyn, Lux, Johannes, Bach, Margund, Cremer, Christoph, Hinderhofer, Katrin, Hausmann, Michael, Hildenbrand, Georg, 2015. In situ optical sequencing and structure analysis of a trinucleotide repeat genome region by localization microscopy after specific COMBO-FISH nano-probing. In: Nanoscale. 7(42), S. 17938 — 17946. ISSN 2040-3364. Abstract
  • Falk, Martin, Hausmann, Michael, Lukasova, Emilie, Biswas, Abin, Hildenbrand, Georg, Davidkova, Marie, Krasavin, Evgeny, Kleibl, Zdenek, Falkova, Iva, Jezkova, Lucie, Stefancikova, Lenka, Sevcik, Jan, Hofer, Michal, Bacikova, Alena, Matula, Pavel, Boreyko, Alla, Vachelova, Jana, Michaelidesova, Anna, Kozubek, Stanislav, 2014. Determining Omics Spatiotemporal Dimensions Using Exciting New Nanoscopy Techniques to Assess Complex Cell Responses to DNA Damage: Part - Structuromics. In: Critical Reviews in Eukaryotic Gene Expression. 24(3), S. 225 — 247. ISSN 1045-4403. Abstract
  • Müller, Patrick, Lemmermann, Niels A., Kaufmann, Rainer, Gunkel, Manuel, Paech, Daniel, Hildenbrand, Georg, Holtappels, Rafaela, Cremer, Christoph, Hausmann, Michael, 2014. Spatial distribution and structural arrangement of a murine cytomegalovirus glycoprotein detected by SPDM localization microscopy. In: Histochemistry and Cell Biology. 142(1), S. 61 — 67. ISSN 0948-6143. Abstract
  • Burger, Nina, Biswas, Abin, Barzan, Daniel, Kirchner, Anne, Hosser, Hiltraud, Hausmann, Michael, Hildenbrand, Georg, Herskind, Carsten, Wenz, Frederik, Veldwijk, Marlon R., 2014. A method for the efficient cellular uptake and retention of small modified gold nanoparticles for the radiosensitization of cells. In: Nanomedicine: Nanotechnology, Biology and Medicine. 10(6), S. 1365 — 1373. ISSN 1549-9634. Abstract
  • Falk, Martin, Hausmann, Michael, Lukasova, Emilie, Biswas, Abin, Hildenbrand, Georg, Davidkova, Marie, Krasavin, Evgeny, Kleibl, Zdenek, Falkova, Iva, Jezkova, Lucie, Stefancikova, Lenka, Sevcik, Jan, Hofer, Michal, Bacikova, Alena, Matula, Pavel, Boreyko, Alla, Vachelova, Jana, Michaelidesova, Anna, Kozubek, Stanislav, 2014. Determining Omics Spatiotemporal Dimensions Using Exciting New Nanoscopy Techniques to Assess Complex Cell Responses to DNA Damage: PART A-Radiomics. In: Critical Reviews in Eukaryotic Gene Expression. 24(3), S. 205 — 223. ISSN 1045-4403. Abstract
  • Kaufmann, Rainer, Müller, P, Hildenbrand, Georg, Hausmann, Michael, Cremer, Christoph, 2010. Analysis of Her2/neu membrane protein clusters in different types of breast cancer cells using localization microscopy. In: Journal of Microscopy. 242(1), S. 46 — 54. ISSN 0022-2720. Abstract
  • Wiech, Thorsten, Stein, Stefan, Lachenmaier, Victoria, Schmitt, Eberhard, Schwarz-Finsterle, Jutta, Wiech, Elisabeth, Hildenbrand, Georg, Werner, Martin, Hausmann, Michael, 2009. Spatial allelic imbalance of BCL2 genes and chromosome 18 territories in nonneoplastic and neoplastic cervical squamous epithelium. In: European Biophysics Journal. 38(6), S. 793 — 806. ISSN 0175-7571. Abstract
  • Wagner, Christian, Hildenbrand, Georg, Spöri, Udo, Cremer, Christoph, 2006. Beyond nanosizing: an approach to shape analysis of fluorescent nanostructures by SMI-microscopy. In: Optik. 117(1), S. 26 — 32. ISSN 0030-4026. Abstract
  • Hildenbrand, Georg, Rapp, Alexander, Spöri, Udo, Wagner, Christian, Cremer, Christoph, Hausmann, Michael, 2005. Nano-Sizing of Specific Gene Domains in Intact Human Cell Nuclei by Spatially Modulated Illumination Light Microscopy. In: Biophysical Journal. 88(6), S. 4312 — 4318. ISSN 0006-3495. Abstract
  • Failla, Antonio Virgillo, Albrecht, Benno, Spöri, U., Schweitzer, A., Kroll, A., Hildenbrand, Georg, Bach, M., Cremer, Christoph, 2003. Nanostructure Analysis Using Spatially Modulated Illumination Microscopy. In: Complexus. 1(2), S. 77 — 88. ISSN 1424-8492. Abstract
  • Hausmann, Michael, Winkler, Ralph, Hildenbrand, Georg, Finsterle, Jutta, Weisel, Andrea, Rapp, Alexander, Schmitt, Eberhard, Janz, Siegfried, Cremer, Christoph, 2003. COMBO-FISH: specific labeling of nondenatured chromatin targets by computer-selected DNA oligonucleotide probe combinations. In: BioTechniques. 35(3), S. 564 — 577. ISSN 0736-6205. Abstract
  • Hikmat, Wisam Mohammed, Sievers, Aaron, Hausmann, Michael, Hildenbrand, Georg, Peculiar k-mer Spectra Are Correlated with 3D Contact Frequencies and Breakpoint Regions in the Human Genome. In: Genes. 15(10).